Default Apps Keep Changing

For multiple programs and file types my changes in default apps do not "stick" after rebooting/restarting. This happens with Entourage, Acrobat, and others. What can I do to get my defaults application assignments to be stable?
Thanks,
Mike

Sounds like a hosed LaunchServices database. Run this command (one-liner) in the Terminal.app (/Applications/Utilities/) by copying & pasting it in, and hit the return key:
*/System/Library/Frameworks/CoreServices.framework/Versions/A/Frameworks/LaunchS ervices.framework/Versions/A/Support/lsregister -kill -r -domain local -domain system -domain user*

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