Differential inputs or pseudodifferential PXI-4461 inputs

I am wondering aboout the pseudodifferential an differential inputs of the PXI-4461
I am doing measurements on switch mode amplifiers where the outputs are bridged and not really ground (PGND) referenced. The input is ground (AGND) referenced to a 5V section. Due to switching currents, AGND and PGND can fluctuate relative each other.  
I understand that the pseudo-differential inputs means the inputs are decoupled from ground and therefore suitable for common mode noise reduction. Differential are fully differential per input.
Is there any performance (accuracy) downside to the fully differential mode, compared to pseudo-differential?
How are maximum voltages specified for fully differential mode (max voltage relative to ground)?
Can I use one input channel of the PXI-4461 in differential mode, one in fully differential?
Thanks

I believe the information in this link would be helpful: Pseudodifferential versus Differential Input Configurations

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