Disable external hard drive to prevent waiting for file open

I have a 1.5TB LaCie external drive I use exclusively for Time Machine. Whenever I try to open a file in Word or other apps, I find I'm waiting for the LaCie drive to spin up before I get a dialog box. I've excluded the drive from Spotlight searches but am wondering if anyone knows of a way to exclude it more broadly so I'm not waiting for it.
Thanks,
John

run the following terminal command. It will rebuild Launch Services database and may fix this issue.
/System/Library/Frameworks/CoreServices.framework/Versions/A/Frameworks/LaunchSe rvices.framework/Versions/A/Support/lsregister -kill -r -domain local -domain system -domain user

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