Do any services require a restart after changing Message Retry Interval?

I'm trying combat a "grey-list" issue by changing the Message Retry Interval to 15 min from 1 min. I did this change about 12 hours ago and
I my test messages are still sitting in queue. I suspect a service restart is needed. Any ideas?
Set-TransportServer SAC79906MAILP01 -MessageRetryInterval 00:15:00
Thanks much! :-)

Hi CalAdmin,
Exchange 2007 Hub Transport definitely required a restart for that Change :
http://blogs.technet.com/b/exchange/archive/2006/11/17/configuring-exchange-2007-hub-transport-role-to-receive-internet-mail.aspx
Tested your Setting in our lab, also :) after a restart at least the Setting is effective/working.
Regards,
Martin

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Our Env... is XI 3.0 and this is related to produciton env.
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Thanks for the update,
Let me say few points about this particular problem:
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2>Now the first sys(RP1) is recieving the data successfully from XI , and the second one (RY1) is getting failed .And this started after changing the Business system 871 to 100 .
3>As mentioned by you , I have checked all the points mentioned
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I have translated the error log into english from the CC monitoring for this interface which is in portuguese language .
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RFC_ERROR_LOGON_FAILURE: 871 Mandante not in the system (select principal existing)
Kindly advise me what to do ..for fixing this problem(this is pretty urgent and it is production env...)..
If any information required , I can provide that.
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Checking for service rpcbind                                                                                                                                                       running
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/dev/ttyS0 at 0x03f8 (irq = 4) is a 16550A
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