Does anyone else have problems opening iTunes 12.1.2.27?

Apple's Software Update asked me to update Yosemite to 10.10.3 and iTunes to 12.1.2.27 today.  I do so and restarted, and the "Software Update" window underneath the Apple icon seems to indicate it worked (it shows as having been updated).  The Get Info box on iTunes says it is version 12.1.2.27.
However, iTunes will not open. I actually redownloaded it and got the same result. The icon appears to want to open (i.e., the "ripple" emanating from the center of the icon shows) but nothing happens. The behavior is the same whether I press Cmd-O select "Open" from the Finder's file menu. Any suggestions?

I had the same problem.
I thought installing iTunes again would solve it. It didn't. I first had to just delete the iTunes.app in the Applications folder. Don't remove any preferences or anything. For me it really worked with just deleting the iTunes.app and then reinstalling.
I followed these steps from user Ben.d on this forum.
Download iTunes from https://www.apple.com/itunes/download/
Open the Terminal
Run "sudo rm -r /Applications/iTunes.app"
Re-install iTunes
Now it runs again smoothly.

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