Does anyone know why I get varying file sizes when I save a jpg (with same settings-None, 12, base "standard", preview checked) from PhotoshopCS5?

I opened a .psd file (300 ppi, CMYK, .jpgs (1626px x 2130px), I saved it as a jpg (None, 12, base "standard", preview checked).
I then closed the original .psd file.
I repeated those steps on the same file and saved a series of 6 .jpgs.
Of those 6 files, I received 2 large files (6.2MB) and 4 smaller (3.2MB) files.
My coworkers who were having trouble opening some of my jpg images in Windows Photo Gallery on Vista OS were able to open the smaller files but not the larger ones.
Do you have any idea why the same settings would give me different file sizes from CS5?
Is there a way I can make it consistently keep the smaller more compatible version?

How well a image data compresses depends on image content.   Image with High detail do not compress well image will little detail will compress well and the file size will be small. Compare a image of a blank white wall to a wall with a black and white checker board wall paper.  One is all white it white no other detail  to detail the other has squares that vary in size because of perspective angle and distance a lot of detail must be recorded.
I do not know why they can not open some of your images. File size should not be an issue.   All your image decoded are the same size  Width number of Pixels Height numbers of pixels background layer only for these are jpeg files.

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