Downloading OS 5.0.1 and I keep getting a (-5000) error message

I am trying to update my iPhone 4 to the OS 5.0.1 and I get this error message... "An error occurred while backing up this iPhone (-5000).  Would you like to continue to update this iPhone?  Continuing will result in the loss of all contents on this iPhone." 
Don't want that!  Anyone have any ideas?
Thanks!

I had the same issue.  I closed iTunes, restarted the computer and then tried again. This time it would sync.  Another thing I tried was switching USB ports I was connecting through.

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