Dynamic SMTP Port Error -Class not Registered

Hi,BizTalk receiving the Invoice Message from Source and doing some transformation.After that Biztalk will send  email  dynamically via SMTP .Below is the code in message construct message assignment shape
multipartMessage1.MessagePart_1= XMLdoc;
multipartMessage1.MessagePart_2="This is message part2 as a string";
multipartMessage1(SMTP.Subject) ="Email From Dynamic Port";
multipartMessage1(SMTP.From) ="[email protected]";
multipartMessage1(SMTP.SMTPHost) ="100.110.120.99";
multipartMessage1.MessagePart_2(MIME.FileName) = "Attachment_Name";
multipartMessage1(SMTP.SMTPAuthenticate) =0;
SendInvoicePort(Microsoft.XLANGs.BaseTypes.Address)="mailto:[email protected]";
When run the application, getting below error message.
A message sent to adapter "SMTP" on send port "HelloWorld_1.0.0.0_Microsoft.Samples.BizTalk.HelloWorld.HelloSchedule_SendInvoicePort_d7ce16ba803d4f87"
with URI "mailto:[email protected]" is suspended.
 Error details: Class not registered
 MessageId:  {0D6BBA1A-F384-4AD9-8B48-44A9C342DEFB}
 InstanceID: {EAFEADE1-8D05-4A7D-A908-7BC297788D06}
After googling ,I have added
multipartMessage1 (SMTP.EmailBodyTextCharset) = "UTF-8".but no use.
I’ve spent many hours on this issue .Please advise how to resolve this issue

Hi Singam,
What is the default handler(host) configured for SMTP Adapter. Check it is 32 bit or 64 bit.
This seems to be a known issue if Host is of 64 bit.
Retrieving the COM class factory for component with CLSID {254B4003-2AA7-4C82-BB2E-18BA7F22DCD2} failed due to the following error: 80040154 Class not registered (Exception from HRESULT: 0x80040154 (REGDB_E_CLASSNOTREG)).
When you use BizTalk in 64 bit version, and the Mime/Smime encoder you’ve got this error. To resolveit, just put your pipeline on a 32 bit Host.
Mime/SMIME encoder error :
Class not registered (Exception from HRESULT: 0×80040154 (REGDB_E_CLASSNOTREG)) 
http://social.technet.microsoft.com/wiki/contents/articles/7204.biztalk-server-list-of-errors-and-warnings-causes-and-solutions.aspx
As you are using Dynamic Send Port it will run under the default host make it of 32 bit, restart the host and see if the issue is resolved or not.
Thanks,
Prashant
Please mark this post accordingly if it answers your query or is helpful.

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