Email cannot send to some domains(error message: 451 4.4.2 Connection dropped due to Socket Error)

We have an Exchange 2010 but could not able to send emails to some domains only.
Checked on some posts but could not find the solution. Pls help on this

Hi DennisMak,
I recommend you refer to the following methods to troubleshoot the issue:
1.Please check if there are any 3rd party firewall feature to cause this issue.
2.Check if these domains in blacklist.
Here is an similar thread for your reference:
http://social.technet.microsoft.com/Forums/en-US/de373066-177a-4743-b6a1-1679fe8bf626/421-442-connection-dropped-due-to-socketerror?forum=exchangesvrsecuremessaginglegacy
Best regards,
Niko
Niko Cheng
TechNet Community Support

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Hi,
I'm getting this error when attempting to send messages to a domain rcmoore.com. I'm unable to send or receive messages from this domain. And my exchange 2010 queue viewer gives me an error
: 451.4.4.0 Primary target ip address responded with 421.4.4.2 connection dropped due to socket error " attempted failover to alternate host, but did not
succeed. Either there are no alternate hosts, or delivery failed to all alternate hosts.
Please help.
Subin Suresh

Hello Subin,
Have you tried a telnet to port 25 of the sending domain from the Hub transport/edge (if edge is presented)? This is required a success send. If this is not an issue, try Unchecking of "Enable Domain Security" at the properties
of the send connector and do a test
Regards from Visit ExchangeOnline |
Visit WindowsAdmin

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Email Stuck - SMTP Relay To Remote Active Directory Site 451 4.4.0 Primary target IP address responded with: ""421 4.4.2 Connection dropped due to SocketError

hi All,
I have 2 HT, located different AD Site. HT1 located in HO Site, and HT2 located in Branch Site.
User from HO site can send email to branch site, but user from branch site cannot send email to HO site.
I found this error on Queue Viewer Console:
451 4.4.0 Primary target IP address responded with: ""421 4.4.2 Connection dropped due to SocketError."" Attempted failover to alternate host, but that did not succeed. Either there are no alternate hosts, or delivery failed
to all alternate hosts
disable all receive connector except default connector still no luck. Telnet SMTP to HT1 from HT2 is working fine.
Event Viewer warning, event ID: 2006.
Send connector Intra-Organization SMTP Send Connector: the connection to IPHT1:25 was disconnected by the remote server.
Send SMTP Log:
2014-03-10T07:11:50.624Z,Intra-Organization SMTP Send Connector,08D109CB5D495BDE,19,IPHT2:57231,IPHT1:25,-,,Remote
2014-03-10T07:21:50.716Z,Intra-Organization SMTP Send Connector,08D109CB5D495C06,0,,IPHT1:25,*,,attempting to connect
2014-03-10T07:21:50.763Z,Intra-Organization SMTP Send Connector,08D109CB5D495C06,1,IPHT2:15741,IPHT1:25,+,,
2014-03-10T07:21:50.825Z,Intra-Organization SMTP Send Connector,08D109CB5D495C06,2,IPHT2:15741,IPHT1:25,<,"220 IPHT1.jakarta.com Microsoft ESMTP MAIL Service ready at Mon, 10 Mar 2014 14:21:50 +0700",
2014-03-10T07:21:50.825Z,Intra-Organization SMTP Send Connector,08D109CB5D495C06,3,IPHT2:15741,IPHT1:25,>,EHLO IPHT2.jakarta.com,
2014-03-10T07:21:50.872Z,Intra-Organization SMTP Send Connector,08D109CB5D495C06,4,IPHT2:15741,IPHT1:25,<,250-IPHT1.jakarta.com Hello [IPHT2],
2014-03-10T07:21:50.872Z,Intra-Organization SMTP Send Connector,08D109CB5D495C06,5,IPHT2:15741,IPHT1:25,<,250-SIZE 104857600,
2014-03-10T07:21:50.872Z,Intra-Organization SMTP Send Connector,08D109CB5D495C06,6,IPHT2:15741,IPHT1:25,<,250-DSN,
2014-03-10T07:21:50.872Z,Intra-Organization SMTP Send Connector,08D109CB5D495C06,7,IPHT2:15741,IPHT1:25,<,250-ENHANCEDSTATUSCODES,
2014-03-10T07:21:50.872Z,Intra-Organization SMTP Send Connector,08D109CB5D495C06,8,IPHT2:15741,IPHT1:25,<,250-STARTTLS,
2014-03-10T07:21:51.091Z,Intra-Organization SMTP Send Connector,08D109CB5D495C06,9,IPHT2:15741,IPHT1:25,<,250-X-ANONYMOUSTLS,
2014-03-10T07:21:51.091Z,Intra-Organization SMTP Send Connector,08D109CB5D495C06,10,IPHT2:15741,IPHT1:25,<,250-AUTH NTLM,
2014-03-10T07:21:51.091Z,Intra-Organization SMTP Send Connector,08D109CB5D495C06,11,IPHT2:15741,IPHT1:25,<,250-X-EXPS GSSAPI NTLM,
2014-03-10T07:21:51.091Z,Intra-Organization SMTP Send Connector,08D109CB5D495C06,12,IPHT2:15741,IPHT1:25,<,250-8BITMIME,
2014-03-10T07:21:51.091Z,Intra-Organization SMTP Send Connector,08D109CB5D495C06,13,IPHT2:15741,IPHT1:25,<,250-BINARYMIME,
2014-03-10T07:21:51.091Z,Intra-Organization SMTP Send Connector,08D109CB5D495C06,14,IPHT2:15741,IPHT1:25,<,250-XEXCH50,
2014-03-10T07:21:51.091Z,Intra-Organization SMTP Send Connector,08D109CB5D495C06,15,IPHT2:15741,IPHT1:25,<,250-XRDST,
2014-03-10T07:21:51.091Z,Intra-Organization SMTP Send Connector,08D109CB5D495C06,16,IPHT2:15741,IPHT1:25,<,250 XSHADOW,
2014-03-10T07:21:51.091Z,Intra-Organization SMTP Send Connector,08D109CB5D495C06,17,IPHT2:15741,IPHT1:25,>,X-ANONYMOUSTLS,
2014-03-10T07:21:51.122Z,Intra-Organization SMTP Send Connector,08D109CB5D495C06,18,IPHT2:15741,IPHT1:25,<,220 2.0.0 SMTP server ready,
2014-03-10T07:26:51.590Z,Intra-Organization SMTP Send Connector,08D109CB5D495C06,19,IPHT2:15741,IPHT1:25,-,,Remote
2014-03-10T07:26:51.590Z,Intra-Organization SMTP Send Connector,08D109CB5D495C0E,0,,IPHT1:25,*,,attempting to connect
2014-03-10T07:26:51.636Z,Intra-Organization SMTP Send Connector,08D109CB5D495C0E,1,IPHT2:15794,IPHT1:25,+,,
anyone have a clue?
thanks.
Endrik
Endrik | blog: itendrik.wordpress.com Please remember to click “Mark as Answer” on the post that helps you, and to click “Unmark as Answer” if a marked post does not actually answer your question. This can be beneficial to other community members reading
the thread.

Hi Niko,
I already disable IPv6 and IPv4 checksum offloading, also check the MTU on each HT but still no luck.
I found the following error on the Netmon:
i already tls on receive connector, enable anonymous authentication, still no luck.
any idea?
thanks.
Endrik
Endrik | blog: itendrik.wordpress.com Please remember to click “Mark as Answer” on the post that helps you, and to click “Unmark as Answer” if a marked post does not actually answer your question. This can be beneficial to other community members reading
the thread.

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Hi,
Following the upgrade to iOS 7.0.3 on all our iPhone and iPad devices, it has been identified that when sending emails around 100KB in size and over an error message appears on the device stating “Cannot Send Mail The message was rejected by the server because it is too large.” See error message below. The send/receive limit is over 10MB so this is not the issue.
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Are you using an email client or webmail? How long ago did this problem occur? Do you know how many accounts are affected?
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If you like a post, or want to say thanks for a helpful answer, please click on the Ratings star on the left-hand side of the post. If someone answers your question correctly please let other members know by clicking on ’Mark as Accepted Solution’.

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