Email "new" and "reply" button not working OS 10.4.11 please help

The buttons in Email "new" and "reply"  not working OS 10.4.11
Internet is working. I go in > Mail preferences > Viewing ... I am not able to see anything or change anything in the Viewing
"Reply-Reply All-Forward" and "New" Buttons in the Mail application are nonresponsive
Any thought. Thanks fior your advice!

Hi Joel,
Safe Boot, (holding Shift key down at bootup), & use Disk Utility from there to Repair Permissions
Reapply the big10.4.11 combo...
The combo update for PowerPC-based Macs...
http://www.apple.com/support/downloads/macosx10411comboupdateppc.html
The combo update for Intel-based Macs...
http://www.apple.com/support/downloads/macosx10411comboupdateintel.html
Repair Permissions afterwords, reboot.

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