EP5 SP5 Security Patches

We have applied MS security patches to our EP5 Install and now we are unable to logon...
We get "The logon credentials supplied were incorrect. Make sure your user name and password are correct, and then try again." Every time the user tries to logon.
We have uninstalled all the patches and still get the same error.
I've reverted back to the default profile and logged on as Admin. I can browse to the Groups Root, People Root, User... Authenticate against an ADS user... However when I select this as the Current Configuration and restart the server. I get the same error...
Any ideas?
Regards
Javid

You can download any Reader updates from http://www.adobe.com/support/downloads/product.jsp?product=10&platform=Windows

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