Epson 4490 Scanner won't work, Epson 1260 does- recent upgrade 10.4.4

I just upgraded last week to 10.4.4 and my Epson Perfection 1260 scanner software didn't want to load. I hooked the USB directly to computer (from USB hub) and no problems. This week I bought an Epson Perfection 4490 (have LOTS of slides to scan) and the application will not open. I keep getting error messages "The application Epson Scan quit unexpectedly."
I have installed and uninstalled software from disc w/ scanner.
I have downloaded software from Epson site.
I have tried the www.hamrick.com software (that gives me the message that I don't have a scanner hooked up.)
I have reparied disc permissions. I have run DiskWarrior.
The system lists the scanner in the USB port, but ImageCapture can't 'see' it.
Any thoughts? I emailed Epson tonight.
Any ideas for Mac-compatible scanner that does 4 or more slides at a time if I can't get this (^%#_#) scanner to work?
Thanks so much for your advice.

I know I'm going to sound redundant here, but I have solved my problems with the Epson 3170 every time by trashing all the software associated with Epson scanner & Smart Panel; then reinstalling from the original CD that came with the scanner (including Smart Panel); then installing all the patches in chronological order from the Epson website. I've had to do this 3 times, with success each time (Jag, Panther, Tiger). It's a lot of work. Here are the exact directions from Epson support to trash all the associated files;
Thank you for contacting the Epson Connection.
To completely uninstall the scanner software please follow the steps below.
UNINSTALL
To ensure that all Epson Scan files have been removed from the system you
would need to check for the following items in the Hard Drive. Please note:
Not all files and locations will be present. If you do not find one of the
items listed, please continue on with the next step.
1. In HD (Hard Drive), APPLICATIONS - remove EPSON SCAN and EPSON SCANNER
MONITOR, if present
NOTE: If you receive an error that EPSON SCANNER MONITOR cannot be deleted
because it is in use, go into HD, APPLICATIONS, UTILITIES and open ACTIVITY
MONITOR. Highlight the EPSON SCANNER MONITOR process and click on QUIT
PROCESS to quit the process. Close ACTIVITY MONITOR. You can now go back
into the APPLICATIONS folder and delete EPSON SCANNER MONITOR.
2. In HD, LIBRARY, APPLICATION SUPPORT - remove the EPSON SCANNER MODULE
folder.
3. In HD, LIBRARY, IMAGE CAPTURE, TWAIN DATA SOURCES - remove the ".ds"
file bearing your scanner's name.
4. In HD, USERS, (YOUR USER NAME), LIBRARY, PREFERENCES - Open the EPSON
folder and then delete the EPSON SCAN folder.
Please Follow the steps below to uninstall your Smart Panel software
1. Insert CD into CD Rom
2. Double-click the SMART PANEL folder
3. Double-click AMERICAN and then SMART PANEL UNINSTALLER
4. Click YES to completely uninstall
5. Restart your computer
6. Go back to CD then SMART PANEL then AMERICAN and click on SMART PANEL
INSTALLER to reinstall your software.
I

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