Error -43: Suddenly can't copy any file to my hard drive.

This error has popped up out of the blue as I've been using the hard drive to store large files for several weeks now. And then tonight, it's suddenly stopped working. Midway through copying a file, it stops, and I get this dialog box:
Here's the specs of the hard drive in question:
Any clue what's going on? Thanks!
Message was edited by: Jeff Ford

HI Jeff,
How much available disk space is there? Right or control click the MacintoshHD icon. Click Get Info. In the Get Info window you will see
Capacity and Available. Make sure you always have a minimum of 10% to 15% free disk space at all times.
First, Quit any open applications/programs. Launch Disk Utility. Select MacintoshHD in the panel on the left, select the FirstAid tab. Click: Repair Disk Permissions. When it's finished from the Menu Bar, Quit Disk Utility and restart your Mac.
Discovered this for Error 43 also. Not sure if it applies. http://support.apple.com/kb/TS2039
Carolyn

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