Error -43 when updating to ios 5

Updated to iTunes 10.5 this morning.  When updating my iPhone 4 (4.3.3) I received the following error:
"An error occurred while backing up the iphone (-43).  Would you like to continue to update this iPhone?  Continuing will result in the loss of all contents on this phone."
Error -43 is not listed on the support page. 
My iPhone has a recent backup from a sync today.  What will happen if I select "continue" and lose the contents on my iphone?

Why is there not a reply from Apple.   Please tell us if we should continue or wait for YOU to fix bug.  What is the delay as your install says this could take hours.

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