Error 54 Can't save this Illustration. The file is locked

I am getting this message from CS4 Illustrator running on Mac 10.6.2 saving back to a WIn 2004 server via SMB connection. The file will save ok the first time, but from then on, the error 54 persist until you close the file and re-open it.
Has anyone seen this issue and been able to resolve it?
Thanks

From a Windows prespective it seems as thought the Error 54 means the network is busy. Sounds like it might be a time sync problem.

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