Error Code  "-10810" under 10.5.7

G'day folks,
While troubleshooting a printer issue I am happening I was reminded of another problem I am having...every now and then my macbook will decide that it doesnt want to open any more programs (with only firefox, entourage and powerpoint running). I get an error saying:
"The application "insert app name" cannot be launched.
-10810
Any suggestions?
Cheers, Brett

The following have been suggested as possible solutions:
1. Get rid of the following:
/Library/Caches/com.apple.LaunchServices-####.csstore (#### is a number)
/Home/Library/Preferences/com.apple.LaunchServices.plist
2. If you have Virex or other virus software installed, try uninstalling it. Be sure to use uninstallers that come with the software because simply deleting the application does not fully uninstall most virus software.
After deleting the referenced files above you will want to do a restart. Then use Disk Utility in your Utilities folder to repair permissions.

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