Error in transaction code SOST for sending PO by EDI

Hi All,
While using SOST the mail is not getting triggered & I am getting the foloowing error. Could anyone help me out.
Message cannot be transferred to node SMTP due to connection error (final)
Message no. XS816
Diagnosis
Due to a technical fault, the system could not set up a connection to the RFC destination Check port and mail server for SMTP nodes. Therefore, the message could not be transferred to node SMTP.
System Response
The system was unable to transfer the message.
Additional information of the node used (in the system language of the node):
Procedure
Check the connection from SAP system to node SMTP. Perhaps the node is not assigned to the correct RFC destination. If so, correct this in Customizing.
Otherwise use RFC destination management to check the RFC connection to destination Check port and mail server for SMTP nodes.
If R/3 is in productive operation, it is advisable to reroute provisionally to another node.
You should therefore notify your system administrator.
Thanks,
Nandan.

Hi Nandan,
Did you find the solution to the error.
I am facing the same error.
Please share the resolution if you found.

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