Error message: "Can't open file "[File path, file name].key"

If I attempt to open any Keynote files, I now get this error message.
"Can't open file "[File path: file name].key"
To clarify, the text in the square brackets above would be the file path and then the file name.
The file then will appear on the screen, but is unresponsive to any clicks or menu commands.
The files will open successfully on other Macs, so they aren't corrupt.
Also - I've just checked, and opening Keynote and trying to create a new presentation leads to the same problem: All screen menus / buttons are dead - all I can do is drag the window around the screen.
I've tried to reinstall Keynote, but this hasn't resolved the problem.
Is there some corrupt preference file (or similar) that I need to get rid of? Is there an easy way to do a complete uninstall of Keynote so I can try another install? Or is this a symptom of something else?
All ideas gratefully appreciated!
Message was edited by: Brendan Donlon

All the issues I describe in my questions around this time re: Keynote were actually symptoms of a soon-to-die laptop. The Hard Disc was corrupting, and Keynote was the first application to be affected.

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