Error trying to update to itunes 10.6.3 & now 10.7 (e drive?)

Error trying to update to itunes 10.6.3 & now 10.7 (e drive?)
I've been having this problem for a while (maybe a couple of months) and avoided it until I updated my iPad and iPhone to iOS 6. Now they won't sync! :|
At first it was simply collapsing after the install process. I've tried again tonight and it is saying that it has an E drive error. I've tried to use the instructions on other discussions (using Run, CMD, and mapping the E drive to C) - but, I don't actually have an E drive. My c used to be split into two, including an E drive, but it has since been returned to one single drive. (I'm a teacher, the IT manager at school sorted this - managing one drive is easier for me to keep it working well - until now).
Itunes was reinstalled and set up simply in the C drive, but could there be something remaining from it's previous install? Help?!?
Thanks,
Luke

many thanks.
There's a few suggestion other than using SUBST at the command prompt given in the following user tip:
"Invalid drive X:\" install errors
Do any of the alternate methods work for you?

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