Error when opening PDF

Hello,
I'm having problems when trying to open PDF documents. When I go to open a PDF it tells me it can not open because it is not a valid PDF document but, I am positive that it is a valid PDF document that opens in other apps. How do I fix this??
Thanks you.

What is your operating system?  Reader version?
Can you open that PDF in a text editor, then copy and paste the first two or three lines here in the forum?

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