Error when synchronising MIDI and audio

I just faced a serious problem when playing back my projects, the speed is slowing down, crackle is heard and a pop up states there's an error when synchronising audio and midi and it's necessary to check some external device..what can it be, how can it be solved ?I;m using Novation Nio audio interface and an external hard drive, that's all..anyone has the same problem?

Hi,
First up your *Audio I/O buffer* (to 1024) in Logic>Preferences>Audio>Devices. Leave the I/O safety buffer off. Perhaps try to freeze some tracks.
Also have a look at these:
http://support.apple.com/kb/TA24535?viewlocale=en_US
http://support.apple.com/kb/HT3161
regards, Erik.

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