Excel 2008 - Intermittent Hang-up when Opening .xls

Hi Everyone,
Sorry if this is posted in the wrong forum - I thought at first I could put it in the "Windows software" forum, but since it wasn't related to Bootcamp or networking, I figured I'd put it here (since it is in fact on a MacBook).
Anyway, here's the issue. You'll find it is quite interesting...
I have a client using a MacBook running 10.5.8 and Office 2008 (12.2.3). She is attempting to open an Excel spreadsheet (in 2004 .xls format) from a website. Firefox 4.0.1 is the browser.
When she downloads the file and chooses "Open with...", Excel begins to launch. However, it does not come into focus (i.e. Firefox is still the application in focus). All the menu items disappear, and the pinwheel appears. At this point, she cannot click on the menu bar/dock/etc. Only after opening Force Quit with the keyboard shortcut is she able to force quit Excel (which is not responding). After that, all returns to normal operation.
Here is where it gets interesting.
1. If, when downloading the .xls file, she chooses "Save" instead of "Open With" and then navigates to it within the Finder and double-clicks on it, the same issue occurs.
2. Iff she opens Excel by itself (clicking the dock icon or otherwise), Excel opens fine and she can create a new spreadsheet, edit an existing one, etc.
3. From within Excel, if she goes to the File > Open menu and navigates to the .xls file in question, it opens without issue.
4. If she opens Excel by itself first and THEN opens the file directly from the website, it opens without issue.
The only consistency I've been able to find so far is this:
When opening Excel by itself, three processes start up: Excel, Microsoft AU Daemon, and Microsoft Database Daemon. When all three of these processes are running, the file opens.
When opening the .xls file directly from the website or by double-clicking on it within the finder, only the Excel process starts. The other two never start, and after a few seconds, the Excel process stops responding. I have not been able to figure out why these two processes are playing such a large part, considering they are primarily for updating Office and running an Entourage database (which she is not doing).
Here is all the troubleshooting done thus far:
- When opening the file on a 10.4.11 machine running Office 2004, it opens fine (directly from site, from Finder, and from Excel open menu).
- When opening the file on a 10.6.7 machine running Office 2008 (12.2.6), it opens fine (directly from site, from Finder, and from Excel open menu).
- A coworker of mine reinstalled Office 2008 entirely
- I have trashed the com.microsoft.Excel.plist file from ~/Library/Preferences
- I have trashed her entire Microsoft User Data folder from ~/Documents
- Updated her Office to version 12.2.9
- Ran Permission Repair
- Ran Disk Verify
- Tried it under the another user profile on her machine. That profile had the same issue.
- Tried rebuilding her database using the Microsoft Database Utility
- Stopped the SMARTBoard "Aware" process and deleted Aware.app (I had another user whose Excel would crash due to this app running)
I'm out of ideas. The only decent workaround I've been able to give her so far was to just open Excel by itself first so that it is running in the background. That way, she can at least open the .xls file.
Any ideas would be much appreciated!

Sorry if this is posted in the wrong forum
Office questions should be posted on Microsoft's own forums for their Mac products:  http://www.officeformac.com/productforums

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