Exchange 2010 edge antispam gone crazy

Hello,
So we have an exchange 2010 infrastructure, with 2 edge servers laying in the DMZ with edgesync configured.
Now we also had that option to "block messages sent to recipients that do no exist in directory" enabled, all was good until a few days ago, when it went berserk and started blocking everyone, with an NDR "550 5.1.1 user unknown". so
now it's disabled.
Few changes that might have caused this, is that we added a new tree domain under the same forest, it's been prepared so exchange can see it. not sure if that could have caused this?
Any ideas?

Hi Abdallah,
According to the description, I notice that all users on our Exchange server can’t receive messages, and senders get NDR “550 5.5.1 User unknown”.
Following article relates to Anti-Spam mail flow, for your reference:
http://technet.microsoft.com/en-us/library/aa997242.aspx
How is the impact, all senders are blocked by the Edge server or some specific senders?
Based on the link above, I suggest double check the configuration on both “Connection Filtering” and “Sender Filtering”.
More details to check:
1. Whether the Sender IP in the IP Block List.
2. Whether the Sender IP in the IP Block Provider’s RBL.
3. Whether the Sender address from Blocked domain.
4. Whether the Message from Blocked sender.
5. Whether the Recipient from Block List.
Pleas also try to re-start Active Directory Lightweight Directory Services for testing.
Please double check the Receive Connector configuration.
If there is any related Error message in App Log, please paste it in details without sensitive information for the further troubleshooting.
Best Regards,
Allen Wang

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