Exchange 2010, Outlook 2010, some clients receive "server unavailable" when logging into outlook

We have a single exchange 2010 server running hub, cas, and mailbox as a virtual machine in VM 5. Currently on version 14.3 build 123.4 running on Server 2008 R2. Clients connecting to this server are all running Outlook 2010 with a mix of OS between
xp and win 7. Domain controllers are all 2003 sp2. We have a multi-campus environment with most users accessing across a WAN connection (mpls and metro-e). Quota Limits of 1gig imposed on all mailboxes. We do still
have a Exchange 2003 server that we are completing the migration of users off of in our environment. But all mailboxes on exchange 2010 are accessed thru Outlook 2010. Migration from 2003 to 2010 happens only after Office 2010 is installed.
We are a little over 50% migrated - (~750 users, 1100 entities)
I have some 2010 clients complaining that they receive "the server is unavailable" when launching outlook for the first time in the morning. A second time it usually opens. This happens for remote WAN and local LAN users. Also,
during the day as outlook is open, when trying to open an email or navigate between folders in the inbox they will also have outlook stop responding as it tries to contact the server.
Monitoring the server - CPU averages 40-50% thru the day with spikes in the 75-100%. Usually the processes that spike are Store.exe or msftefd.exe.
I have verified that IPV6 is disabled on the exchange server - and it doesn't exist on the 2003 DC's. Searching for answers keeps turning up results for OOF or Outlook 2003 RPC. Neither are the case here.
Would we benefit from adding a 2nd server into our environment? If so - hub? Cas? which would be better to offload off the primary?
or is there a better way to handle this issue?

Hi,
According to your description, the issue happens on every morning. Thus, it’s mostly likely caused by that there are too many sessions bringing the performance issue.
To confirm it, we can use performance monitor to check the following counters when Outlook works slowly:
RPC request, RPC average latency and RPC operation/sec
http://technet.microsoft.com/en-us/library/dd335215(v=exchg.141).aspx
If you have any question, please feel free to let me know.
thanks,
Angela Shi
TechNet Community Support

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[Thu Oct 23 21:07:39 2008] [debug] oc4j_ajp13_worker.c(1000): [client 10.98.35.34] [ecid: 1224810459:10.98.35.34:897262:0:75,0] MOD_OC4J_0040: Request: header_name[2]: Accept-Language, header_value[2]: en-us.
[Thu Oct 23 21:07:39 2008] [debug] oc4j_ajp13_worker.c(1000): [client 10.98.35.34] [ecid: 1224810459:10.98.35.34:897262:0:75,0] MOD_OC4J_0040: Request: header_name[3]: Connection, header_value[3]: Keep-Alive, TE.
[Thu Oct 23 21:07:39 2008] [debug] oc4j_ajp13_worker.c(1000): [client 10.98.35.34] [ecid: 1224810459:10.98.35.34:897262:0:75,0] MOD_OC4J_0040: Request: header_name[4]: Host, header_value[4]: rlap1s2k.poloralphlauren.com:7788.
[Thu Oct 23 21:07:39 2008] [debug] oc4j_ajp13_worker.c(1000): [client 10.98.35.34] [ecid: 1224810459:10.98.35.34:897262:0:75,0] MOD_OC4J_0040: Request: header_name[5]: TE, header_value[5]: trailers, deflate, gzip, compress.
[Thu Oct 23 21:07:39 2008] [debug] oc4j_ajp13_worker.c(1000): [client 10.98.35.34] [ecid: 1224810459:10.98.35.34:897262:0:75,0] MOD_OC4J_0040: Request: header_name[6]: User-Agent, header_value[6]: Mozilla/4.0 (compatible; MSIE 6.0; Windows).
[Thu Oct 23 21:07:39 2008] [debug] oc4j_ajp13_worker.c(1000): [client 10.98.35.34] [ecid: 1224810459:10.98.35.34:897262:0:75,0] MOD_OC4J_0040: Request: header_name[7]: Oracle-ECID, header_value[7]: 1224810459:10.98.35.34:897262:0:75,0.
[Thu Oct 23 21:07:39 2008] [debug] oc4j_ajp13_worker.c(1053): [client 10.98.35.34] [ecid: 1224810459:10.98.35.34:897262:0:75,0] MOD_OC4J_0044: Request: query string: type=System.
[Thu Oct 23 21:07:39 2008] [debug] oc4j_ajp13_worker.c(1078): [client 10.98.35.34] [ecid: 1224810459:10.98.35.34:897262:0:75,0] MOD_OC4J_0045: Request: jvm_route: e3iQch8KbN4Re34SahuQaNaNaO1ynknvrkLOlQzNp65In0.
[Thu Oct 23 21:07:39 2008] [debug] oc4j_ajp13_worker.c(1240): [client 10.98.35.34] [ecid: 1224810459:10.98.35.34:897262:0:75,0] MOD_OC4J_0050: Request: env_name[0]: OC4J_UNPARSED_URI, env_value[0]: /webapp/servlet/EMDServlet.
[Thu Oct 23 21:07:39 2008] [debug] oc4j_ajp13_worker.c(1253): [client 10.98.35.34] [ecid: 1224810459:10.98.35.34:897262:0:75,0] MOD_OC4J_0109: Request: ajp13 command: FF.
[Thu Oct 23 21:07:39 2008] [debug] oc4j_ajp13_worker.c(1270): [client 10.98.35.34] [ecid: 1224810459:10.98.35.34:897262:0:75,0] MOD_OC4J_0098: Have successfully sent out all the ajp13 headers to the web container.
[Thu Oct 23 21:07:39 2008] [debug] oc4j_ajp13_worker.c(1859): [client 10.98.35.34] [ecid: 1224810459:10.98.35.34:897262:0:75,0] MOD_OC4J_0063: Response status line: 200 OK.
[Thu Oct 23 21:07:39 2008] [debug] oc4j_ajp13_worker.c(1862): [client 10.98.35.34] [ecid: 1224810459:10.98.35.34:897262:0:75,0] MOD_OC4J_0064: Response number of headers: 5.
[Thu Oct 23 21:07:39 2008] [debug] oc4j_ajp13_worker.c(1898): [client 10.98.35.34] [ecid: 1224810459:10.98.35.34:897262:0:75,0] MOD_OC4J_0067: Response header_name[0]: Date, header_value[0]: Date: Fri, 24 Oct 2008 01:07:39 GMT.
[Thu Oct 23 21:07:39 2008] [debug] oc4j_ajp13_worker.c(1898): [client 10.98.35.34] [ecid: 1224810459:10.98.35.34:897262:0:75,0] MOD_OC4J_0067: Response header_name[1]: Content-Type, header_value[1]: text/html.
[Thu Oct 23 21:07:39 2008] [debug] oc4j_ajp13_worker.c(1898): [client 10.98.35.34] [ecid: 1224810459:10.98.35.34:897262:0:75,0] MOD_OC4J_0067: Response header_name[2]: Content-Length, header_value[2]: 14.
[Thu Oct 23 21:07:39 2008] [debug] oc4j_ajp13_worker.c(1898): [client 10.98.35.34] [ecid: 1224810459:10.98.35.34:897262:0:75,0] MOD_OC4J_0067: Response header_name[3]: Set-Cookie, header_value[3]: JSESSIONID=0a62232230d76881608e0f264a5db01fd8741646fd2b.e3iQch8KbN4Re34SahuQaNaNaO1ynknvrkLOlQzNp65In0; path=/webapp; secure.
[Thu Oct 23 21:07:39 2008] [debug] oc4j_ajp13_worker.c(1898): [client 10.98.35.34] [ecid: 1224810459:10.98.35.34:897262:0:75,0] MOD_OC4J_0067: Response header_name[4]: Cache-Control, header_value[4]: private.
[Thu Oct 23 21:07:39 2008] [debug] oc4j_ajp13_worker.c(752): [client 10.98.35.34] [ecid: 1224810459:10.98.35.34:897262:0:75,0] MOD_OC4J_0034: After handling ajp13 response message, got a returned value: 0.
[Thu Oct 23 21:07:39 2008] [debug] oc4j_ajp13_worker.c(752): [client 10.98.35.34] [ecid: 1224810459:10.98.35.34:897262:0:75,0] MOD_OC4J_0034: After handling ajp13 response message, got a returned value: 0.
[Thu Oct 23 21:07:39 2008] [debug] oc4j_ajp13_worker.c(752): [client 10.98.35.34] [ecid: 1224810459:10.98.35.34:897262:0:75,0] MOD_OC4J_0034: After handling ajp13 response message, got a returned value: 5.
[Thu Oct 23 21:07:39 2008] [debug] oc4j_ac_worker.c(391): [client 10.98.35.34] [ecid: 1224810459:10.98.35.34:897262:0:75,0] MOD_OC4J_0122: Serviced request with network worker: home_15.
[Thu Oct 23 21:07:39 2008] [debug] mod_oc4j.c(786): [client 10.98.35.34] [ecid: 1224810459:10.98.35.34:897262:0:75,0] MOD_OC4J_0014: Serviced the request by worker: home.
[Thu Oct 23 21:07:39 2008] [debug] mod_oc4j.c(807): [client 10.98.35.34] [ecid: 1224810459:10.98.35.34:897262:0:75,0] MOD_OC4J_0374: Response was started, returning OK.
[Thu Oct 23 21:07:44 2008] [debug] mod_osso.c(3998): [client 127.0.0.1] [ecid: 10.98.35.34:66740:1224810464214:1483,2] \n[OSSO] ===== REQUEST =====\n[OSSO] GET /dms0/Spy?format=tbml&operation=get&value=false&units=true&description=true&version=9.0.4 HTTP/1.1\n
[Thu Oct 23 21:07:44 2008] [debug] mod_osso.c(367): [client 127.0.0.1] [ecid: 10.98.35.34:66740:1224810464214:1483,2] \n[OSSO] D26: process_idle_time()\n
[Thu Oct 23 21:07:44 2008] [debug] mod_osso.c(808): [client 127.0.0.1] [ecid: 10.98.35.34:66740:1224810464214:1483,2] \n[OSSO] D03: update_request()\n
[Thu Oct 23 21:07:44 2008] [error] [client 127.0.0.1] [ecid: 10.98.35.34:66740:1224810464214:1483,2] File does not exist: /u01/oracle/midtier/Apache/Apache/htdocs/dms0/Spy
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08/10/23 20:27:33 formsweb: Stopped
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08/10/23 20:27:39 Started
08/10/23 20:27:44 formsweb: jsp: init
08/10/23 20:27:44 formsweb: frmservlet: init
08/10/23 20:27:44 formsweb: FormsServlet init():
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08/10/23 23:44:13 Published an event: C_101.98.3.35.2164a99a.11c5210156f.-8000#usncpas2k.localhost.localdomain.com#181863334#D#OC4J_BI_Forms#default_island&localhost.localdomain.com&HTTP:localhost.localdomain.com#12504&RMI:localhost.localdomain.com#12404&JMS:localhost.localdomain.com#12605
default-web-access.log
[23/Oct/2008:23:50:00 -0500] "GET /reports/rwservlet/pingserver HTTP/1.1" 200 3

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Exchange 2010, Outlook 2010, some clients receive "server unavailable" when logging into outlook

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