Exchange 2010 RPC issue, "The RPC_S_SERVER_UNAVAILABLE error (0x6ba) was thrown by the RPC Runtime process"

Hi All,
this is the first time iv had to post on here on a forum since ive been doing IT but here goes.
Server background:
SBS 2011
Exchange 2010 SP3 RU6
Installed 2 years ago and has run relatively smooth since installation
Possible Cause: a recent application that had created a virtual directory in IIS.
Issue:
A user recently reported an issue with Outlook Anywhere, i did an exchange connection test and reported the following error
The RPC_S_SERVER_UNAVAILABLE error (0x6ba) was thrown by the RPC Runtime process.
Elapsed Time: 3834 ms.
Fixes Tried so far
- Reg fix for ports 6001,6002,6004
- Telnet 127.0.0.1 6001 all returns expected results
- Disable RPC then Re-enable via the management console
-Ran fix my network wizard which has shown an error in compenent 3 which it fixed
Component ID #3
If the Fix My network wizard shows that component ID #3 is broken, this means that within IIS the RPC virtual directory settings are incorrect.
Continuing to fix this error within the wizard will correct the RPC virtual directory to support both Basic and NTLM authentication to this virtual directory.
Any suggestions would be great as im running out of ideas, i have thought about rebuilding outlook anywhere but unsure of the implications on an SBS

Hi,
In order to check whether it is an RPC Virtual Directory issue, you can open IE and input:
Https://mail.domain.com/RPC/RPCProxy.dll
After inputting the credential, the expected result is a blank page. If not, I means the issue resides on the RPC VD. You can try rebuilding the RPC VD for the first try.
Thanks,
Simon Wu
TechNet Community Support

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Additional Details
The RPC_S_SERVER_UNAVAILABLE error (0x6ba) was thrown by the RPC Runtime process
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Dear Allen
The Value is already set to 2147483648.
Telnet of the Ports 6001,6002,6004 OK.
I also tested the following:
Test-OutlookConnectivity -RpcTestType:Server -RpcProxyAuthenticationType:Basic -RpcClientAccess
Server:SERVER
ClientAccessServer ServiceEndpoint Scenario Result
Latency
(MS)
Server Server RFRI::GetReferral. Success
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You can refer to the following steps to rebuild an Offline Address Book.
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How to Quickly Rebuild an Exchange 2010 Offline Address Book
http://social.technet.microsoft.com/wiki/contents/articles/7725.how-to-quickly-rebuild-an-exchange-2010-offline-address-book.aspx
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