Exchange 2010: Sender address rejected: Access denied

hi friends
i have been recently experiencing an issue with one of my customer which i send email i get bounce message while i can receive their emails with no issue. i have exchange 2010 installed and im using Anti spam device too. my domain is ok.com
i try to send from OWA as well but i get the same result.
Delivery has failed to these recipients or groups:
[email protected] A problem occurred during the delivery of this
message to this e-mail address. Try sending this message again. If the problem continues, please contact your helpdesk.
Diagnostic information for administrators:
Generating server: antispamServer.ok.com
[email protected] #< #5.0.0 X-Spam-&-Virus-Firewall; host mail.abc.com[22.22.22.12] said: 554
5.7.1 <btv1==14869c83b8f==[email protected]: Sender address rejected: Access denied (in reply to RCPT TO command)> #SMTP#
Original message headers:
any idea?
thanks

hi
when i disable the antispam device i get this error
smtp5.relay.iad3a.emailsrvr.com rejected your message to the following e-mail addresses:
[email protected]
smtp5.relay.iad3a.emailsrvr.com gave this error: <[email protected]>: Sender address rejected: Access denied
Your message wasn't delivered due to a permission or security issue. It may have been rejected by a moderator, the address may only accept e-mail from certain senders, or another
restriction may be preventing delivery.

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    IsSelfSigned       : True
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    NotAfter           : 22/01/2017 13:18:02
    NotBefore          : 22/01/2012 13:18:02
    PublicKeySize      : 2048
    RootCAType         : None
    SerialNumber       : 6925D91285B649BD4D5E4297F1A48471
    Services           : IMAP, POP, IIS, SMTP
    Status             : Valid
    Subject            : CN=server1
    Thumbprint         : 939A37173BF84E352CEDC74F7D9A3D71F498A005
    AccessRules        : {System.Security.AccessControl.CryptoKeyAccessRule, System.Security.AccessControl.CryptoKeyAcc
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    IsSelfSigned       : True
    Issuer             : CN=WMSvc-SERVER1
    NotAfter           : 19/01/2022 12:56:44
    NotBefore          : 22/01/2012 12:56:44
    PublicKeySize      : 2048
    RootCAType         : Registry
    SerialNumber       : 1DB8711F7ADC5CB54196468EF2FF5D21
    Services           : None
    Status             : Valid
    Subject            : CN=WMSvc-SERVER1
    Thumbprint         : 191D86BDE274510453D58DDB91D253DABBCF05F1
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    AddressSpaces                : {SMTP:*;1}
    AuthenticationCredential     : System.Management.Automation.PSCredential
    Comment                      :
    ConnectedDomains             : {}
    ConnectionInactivityTimeOut  : 00:10:00
    DNSRoutingEnabled            : False
    DomainSecureEnabled          : False
    Enabled                      : True
    ErrorPolicies                : Default
    ForceHELO                    : False
    Fqdn                         :
    HomeMTA                      : Microsoft MTA
    HomeMtaServerId              : SERVER1
    Identity                     : Internet
    IgnoreSTARTTLS               : False
    IsScopedConnector            : False
    IsSmtpConnector              : True
    LinkedReceiveConnector       :
    MaxMessageSize               : unlimited
    Name                         : Internet
    Port                         : 25
    ProtocolLoggingLevel         : None
    RequireOorg                  : False
    RequireTLS                   : False
    SmartHostAuthMechanism       : None
    SmartHosts                   : {server7.mydomain.com, server6.mydomain.com}
    SmartHostsString             : server7.mydomain.com,server6.mydomain.com
    SmtpMaxMessagesPerConnection : 20
    SourceIPAddress              : 0.0.0.0
    SourceRoutingGroup           : Exchange Routing Group (DWBGZMFD01QNBJR)
    SourceTransportServers       : {SERVER1}
    TlsAuthLevel                 :
    TlsDomain                    :
    UseExternalDNSServersEnabled : False
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    Luca

    Hi Allen,
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