Exchange 2010 SP3 Rollup 8v2 causes client connectivity issues

I installed SP3 Rollup 8v2 this weekend, going from 7. Since then we are having random client connectivity issues. New profiles can't be created, and some users can't access resources when booking meetings. We can do a registry fix to their machines to add
a DS Server, but this is a workaround only. I have uninstalled the Rollup 8v2 and we are still having the issue.
I thought 8v2 was supposed to fix this issue!

Hi,
According to your post, I understand that outlook client cannot connect to Exchange server to configure profile and cannot get list of resources room when upgrade to Exchange 2010 SP3 Rollup 8v2, the temporary solution is that specify the DC in registry.
If I misunderstand your concern, please do not hesitate to let me know.
Is there error message when configure Outlook failed?
Please run Test E-mail AutoConfiguration and Outlook connection status to double confirm the URL and FQDN of Exchange server.
As additional, please run below command to double check the state of Exchange system component:
Get-ServerComponentstate -Identity “servername”
If the state is Inactive, please run below command to active relevant component:
Set-ServerComponentState <Identity> -Component “component name” -Requester HealthAPI -State Active
More details about Server Component States in Exchange, for your reference:
http://blogs.technet.com/b/exchange/archive/2013/09/26/server-component-states-in-exchange-2013.aspx
Thanks
Please remember to mark the replies as answers if they help, and unmark the answers if they provide no help. If you have feedback for TechNet Support, contact [email protected]
Allen Wang
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