Exchange 2013 mailflow issues & transport latency

Hi,
we have more then 50 Exchange Server 2013 deployed and every single Exchange has transport issues.
-the transport Service do not respond for 30 min or more.
-RAM consumption
-the e-mail are stock in outlook for long time
-we have Exchaneg 2013 with all CUs / SP1 version installed and i cannot see any improvement.
I m disappointed and i hope that someone can help me to understand the Exchange 2013 Mailflow
Best regard

@ 1 i want to say thanks all of you for the Replays and for helpful information.
Yes i have a Transport Agent on the Computer for Archiving S.Nithyanandham
I fix the Problem with the Microsoft Script and now i will wait to see any improvement.
After i set the eventlog to high i can see
event id 12028
The process with process ID 11596 is holding the performance counter connections current Value=0 SpinLock=0 Lifetime=Type: 1 ProcessId: 11596 StartupTime: 130566455797932178 from instance _total(CFBEE918) RefCount=0 SpinLock=0 Offset=32 and category MSExchangeTransport
SmtpSend while running processes are: Processes running are:
5908 w3wp
8468 msdtc
13736 powershell
1964 sftracing
20864 UMWorkerProcess
4128 MSExchangeDagMgmt
3468 Microsoft.Exchange.Diagnostics.Service
1368 mqsvc
4912 w3wp
12988 RuntimeBroker
2152 Microsoft.Exchange.Directory.TopologyService
388 svchost
6876 MSExchangeMailboxReplication
3132 MSExchangeSubmission
2540 MSExchangeMigrationWorkflow
19284 iexplore
2932 noderunner
10416 w3wp
16136 conhost
564 svchost
20352 conhost
1144 Internal.Exchange.CADNArchivingService
2132 WMSvc
12828 ParserServer
4296 scanningprocess
4688 GXHSMService
19244 conhost
17096 Microsoft.Exchange.Imap4Service
22020 vmtoolsd
4092 Microsoft.Exchange.UM.CallRouter
3696 MSExchangeThrottling
5664 Microsoft.Exchange.EdgeSyncSvc
344 csrss
736 svchost
14328 ParserServer
1128 svchost
19660 WmiPrvSE
5904 Microsoft.Exchange.Imap4
2108 svchost
21412 mmc
3464 w3wp
1316 cvd
6040 MSExchangeFrontendTransport
15560 iexplore
916 svchost
1504 hostcontrollerservice
16672 taskhostex
16868 explorer
9972 w3wp
712 svchost
4060 umservice
6620 svchost
6616 w3wp
13116 svchost
704 dwm
7204 Microsoft.Exchange.Store.Worker
15900 iexplore
108 winlogon
24732 conhost
500 lsass
696 Microsoft.Exchange.Store.Service
5816 Microsoft.Exchange.Search.Service
1480 svchost
1280 fms
7976 dllhost
1080 spoolsv
684 LogonUI
22248 mmc
20040 rundll32
10924 w3wp
13612 conhost
6588 MSExchangeMailboxAssistants
21952 conhost
1464 SMSvcHost
23816 mmc
16828 mmc
2640 noderunner
2836 noderunner
4608 EvMgrC
16700 Microsoft.Exchange.SharedCache
5196 w3wp
15636 MSExchangeHMWorker
6396 mmc
9044 Microsoft.Exchange.Imap4Service
4400 SMSvcHost
1836 nsclient++
3016 Microsoft.Exchange.RpcClientAccess.Service
1636 inetinfo
15424 csrss
1436 vmtoolsd
1828 ForefrontActiveDirectoryConnector
9384 w3wp
24148 MSExchangeTransport
6552 w3wp
4384 scanningprocess
4972 Microsoft.Exchange.AntispamUpdateSvc
3788 MSExchangeTransportLogSearch
14644 rundll32
19348 Microsoft.Exchange.Imap4
432 winlogon
22692 conhost
23676 rdpclip
2792 noderunner
4564 scanningprocess
228 smss
5152 MSExchangeDelivery
620 Microsoft.Exchange.ServiceHost
9484 w3wp
22216 ParserServer
5736 MSExchangeHMHost
1992 updateservice
21296 iexplore
21004 dwm
8292 WUDFHost
608 svchost
16768 conhost
396 csrss
5136 Microsoft.Exchange.Store.Worker
800 svchost
11240 w3wp
404 wininit
7692 svchost
9716 w3wp
492 services
4 System
24748 ParserServer
2760 msexchangerepl
0 Idle
event 2006
Send connector Inbound Proxy Internal Send Connector: the connection to xxx.xxx.xxx.x:2525 was disconnected by the remote server.
event 2128
Process w3wp.exe (ECP) (PID=10924). Object CN=HealthMailbox526969de2c35417c8a01222265520c3e,CN=Monitoring Mailboxes,CN=Microsoft Exchange System Objects,DC=domain,DC=dc was not found on the Domain Controller %hostname%. This may indicate a replication or
permission issue. 
event 1012
The store driver failed to submit event 18522569 mailbox d57dd45b-f3e9-492d-b23c-0fea92c8dd85 MDB 7b71f84c-1bd3-4b16-a8a9-dca18f50fbb5 and couldn't generate an NDR due to exception Microsoft.Exchange.MailboxTransport.StoreDriverCommon.InvalidSenderException
   at Microsoft.Exchange.MailboxTransport.Shared.SubmissionItem.SubmissionItemUtils.CopySenderTo(SubmissionItemBase submissionItem, TransportMailItem message)
   at Microsoft.Exchange.MailboxTransport.Submission.StoreDriverSubmission.MailItemSubmitter.GenerateNdrMailItem()
   at Microsoft.Exchange.MailboxTransport.Submission.StoreDriverSubmission.MailItemSubmitter.<>c__DisplayClass1.<FailedSubmissionNdrWorker>b__0()
   at Microsoft.Exchange.MailboxTransport.StoreDriverCommon.StorageExceptionHandler.RunUnderTableBasedExceptionHandler(IMessageConverter converter, StoreDriverDelegate workerFunction).
event id 1023
Windows cannot load the extensible counter DLL ASP.NET_2.0.50727. The first four bytes (DWORD) of the Data section contains the Windows error code.

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