Exchange server 2010 losing connection to DC and GC

Hi,
My Exchange organization includes 2 Mailbox servers, 2 hub/transport servers and 2 edge transport servers.
Everyday, one of my mailbox server loses connection to Dcs. This error is logged :
Process MSEXCHANGEADTOPOLOGYSERVICE.EXE (PID=1976). All Global Catalog Servers in use are not responding:
servername.domain.com
About 10 minutes later, my mailbox server starts again discovering the Dcs and GCs in the domain, all alone, without me doing anything about it.
Process MSEXCHANGEADTOPOLOGYSERVICE.EXE (PID=1976. Exchange Active Directory Provider has discovered the following servers with the following characteristics.....
Fortunatly, it always happen later in the night, between 10 PM and 01 AM everyday when people are not working.
My other Exchange servers don't have this issue.
I have the Exchange 2010 SP3 RU6 installed on all my exchange servers.

Hi,
Please check whether Event ID 2080 login the event viewer.
More details in the following KB:
Event ID 2080 from MSExchangeDSAccess
http://support.microsoft.com/kb/316300
Please focus on the "How to Use the Information in Event ID 2080 to Diagnose DSAccess Problems" session.
Also found this link for your reference:
http://clintboessen.blogspot.com/2012/09/exchange-2010-randomly-loosing-access.html
Disclaimer:
Microsoft is providing this information as a convenience to you. The sites are not controlled by Microsoft. Microsoft cannot make any representations regarding the quality, safety, or suitability of any software or information found there. Please make sure
that you completely understand the risk before retrieving any suggestions from the above link.
Thanks
Mavis
Mavis Huang
TechNet Community Support

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    If you want to use Exchange 2010 as your voicemail system, you need an Exchange server hosting the Unified Messaging server role.  Microsoft has specific requirements for using Exchange unified messaging as well as licensing for your voicemail subscribers.  Here is a good review - http://technet.microsoft.com/en-us/library/bb125141.aspx.  Plus there should be an integration document for voicemail functionality, I found the CUCM version 7 integration doc here - http://www.microsoft.com/downloads/en/details.aspx?FamilyID=d5db0297-7850-4f52-b965-b8006b4c05f5&displaylang=en
    Regards, Ginger

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    My company has been running Exchange Server 2010 SP1 on virtual machine for almost three years. My colleague created this virtual machine (Windows Server 2008 R2 SP1) before Exchange Server installation with following partitions:
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    Yes, its safe to move the DB/Logs. You can follow the procedure mentioned in this article to do it via EMC or Shell... http://exchangeserverpro.com/move-exchange-2010-database-folder/
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    Besides this, upgrade Exchange 2010 SP1 to SP3, SP1/SP2 aren't supported anymore! http://blogs.technet.com/b/rmilne/archive/2014/04/09/end-of-exchange-2010-sp2-support.aspx
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