External drive goes read only with error -50 after time

Running the special release of 10.8.2 for Mac Mini (2012) that was recently released.  I have two external USB drives.  The first contains my iTunes collection and the second is my time machine backup disk.  The iTunes drive seems to go read only after it's been mounted awhile.  I can read files off the drive, but I can't make any changes.  I can't delete files nor edit them. 
If I try to do anything with the disk including a repair permissions or disk on it, I get an error -50.   The only way to get out of this state is to unmount the drive and remount it forcibly or reboot. 
Anyone have ideas on what is going on or experienced a similar issue?  

I did a little more research and there are quite a few people who've seen this error.  I don't think it's the drive. 
I suspect the controller in the enclosure, a jmicron 0x2336, is responsible for my problems.  It looks like Linux and FreeBSD both had software updates to work around bugs in the controller.  If OS X did not get updated, it would explain everything. The drive sleeps and then won't wake up fully and OS X marks it as in error and goes read only. 
The enclosure is a Thermaltake Silver II USB + esata.  It looks like a lot of people have had similar problems with them.  I saw posts on macrumors, adobe's support forums, etc.

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