External Fire Drive - All files cannot be opened

Hi, I have a Prolific PL3507 Combo External Firewire Drive. All data on the device cannot be opened by its application or any application - Photoshop, Illustrator - iTunes - iPhoto - Pages etc etc.
A get info shows the file as being whatever the file is, complete with its application icon, but it will not open "unknown format type" error is reported. Working fine for over a year, then today . . .
iTunes + iPhoto hangs. Copying the file to my desktop doesn't help. If I now create a new Illustrator file and save it to the external, it will open again, but all previous files will not open.
I have run 'Cocktail' + 'Disk Utility' form the install DVD with no success.
Please please please help someone.

Back up all data.
Boot into Recovery by holding down the key combination command-R at the startup chime. Release the keys when you see a gray screen with a spinning dial.
Note: You need an always-on Ethernet or Wi-Fi connection to the Internet to use Recovery. It won’t work with USB or PPPoE modems, or with proxy servers, or with networks that require a certificate for authentication.
When the OS X Utilities screen appears, follow the prompts to reinstall the OS. You don't need to erase the boot volume, and you won't need your backup unless something goes wrong. If your Mac was upgraded from an older version of OS X, you’ll need the Apple ID and password you used to upgrade, so make a note of those before you begin.

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