Fail to load in CS5 - File not compatible

I'm importing a video (tried various video formats) into PS CS5 and when I save without doing any edits the PSD file loads fine.
As soon as I have applied an edit to a frame (e.g. stamp tool, context sensitive fill, etc) the edits are fine and I save the file. The file can now no longer be loaded into PS and comes up the the "not compatible with this version of Photoshop error".
The edit system does not have any form of anti-virus installed.
Any help? I'm kind of stuck and have a bucket load of editing to do,

Hi Steve,
Sorry for slow reply, I've been away.
I'm running Windows 7 (64 bit) and I have tried both the 64-bit and 32-bit versions of Photoshop.
My system spec:
Asus Rampage II Extreme motherboard
i7-980x 6-core/12 thread CPU running at 3.33 GHz
12 GByte of RAM
Gaintech GTX-285 graphics card with 2 GByte of memory
4 drives configured as: C is 1 TByte SATA, D is 1 TByte SATA, E is 2x500 GByte in a RAID 0 array, F is a 2x500 GByte in a RAID 0 array.
I think the system specs are sufficient and doesn't even break a sweat for all the stuff I do
I have tried 8-bit to 32-bit, same problem.
This worked fine on CS4. Unfortunately I don't have CS4 installed since I rebuilt the PC when CS5 arrived (learned to keep my edit PC clean and hence have very few problems).
I have uploaded the files to an FTP server. I'll email the details to you separately.
Thanks,
Nicole

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