Failure to Launch - unknown error (-50)

As the subject says I can no longer launch itunes and when I try I get an unknown error (-50). I uninstalled and reinstalled itunes and quick time. Any suggestions.

Ok, so I created a whole new user called Test.
I hooked up the nano, and it asked if i want to erase and sync, or transfer purchases.
I transferred purchases, so then I had a couple hundred songs in my itunes library.
Then I synced the nano, and got the usual "this nano syncs with another library to you want to erase everything and sync with this one" and i said yes.
It worked.
Then I went and turned on photo syncing (even though I have no photos in this new user account).
It worked.
Then I copied a few folders of pix from my regular user account into the test account's Pictures folder. Then opened iphoto and said 'import to library'. So it added all the pix in the pictures folder into iphoto.
I tried to sync the ipod again- it asked if I wanted to replace all pix with the new ones (the same as the music warning)- I said yes.
And hit sync- and it worked.
Soo... I guess that means the problem is either somewhere in my thousands of photos, or maybe in a pref file for my user?
Maybe the next step is to import ALL my pix from the old account. Then if THEY sync, it must be something in the user account itself?! Not sure if that logic works.
But I don't think my 4gb nano can hold all my pix, and I don't really want to erase my whole 80gb video...
Anyone have any other ideas? Where are the Apple helper people? The only people responding are people saying 'i have the same problem'. Can we get some help around here?
Please?

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