FCP does not work after sleep - asking for quartz extreme card

Hi all,
Well my 2 x 2.266 Dual Core Intel xeon with 5 gig memory is getting a little long in the tooth and I have started coming up against what I suspect is hardware issues.
The OSX is 10.5.8
It has a blackmagic HD card as well as an ESATA rocketraid card.
I have a sohoraid attached as well as a Drobo (via firewire).
In the last couple of months I l've had a bunch of issues that I wonder if are at all related.
Firstly the DVD player app now freezes the whole computer if I try and start it.
when it first did this I spent forever rebuilding the system for it to only fall over again a month or so later.
2) In the last couple of weeks, when I wake from sleep the mouse icon is gone and what is in its place is a small area of distorted,broken pixels. Still works as a mouse (the distorted pixels move round like an arrow) and the arrow returns when I tab through to another application. Weird...
3) In that same time when I have started Final Cut Pro it immediately gives me a warning saying a quartz extreme video vard is required to run application and refuses to open. Restarting computer fixes this but this is a new development.
4) I ran into an issue at beginning of the year with my soho 5bay raid where it said a drive failed and then couldn't rebuild with a new drive, took it to shop and it blinked into life on their computer. Drive was never broken. Its now back and running as it should, like it always did, but they couldn't see what went wrong.
These of course could be a unrelated but I somehow suspect not.
Any first 'go-to's" you would recommend to just try and trouble shoot this?
THANK YOU!!!!

Try these in this order:
1. Set Mac to NEVER SLEEP. No exceptions.
2. Repair Permissions on all drives.
3. Trash Preferences for offending apps.
4. Wipe and re-install fresh OS and apps every 6-18 months.
Tim

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