Files won't open from finder or by dragging to application icon in dock

Clicking or double clicking on a file in finder causes it to blink as if it is opening but it does not open. Dragging the file to its application in the dock causes the application to open but the file does not open. I can only open a file from inside an application using File > Open.

Welcome to Apple Discussions.
First of all, are running you have any third party apps that change your system appearance?
If so, try removing them from login items (see below).
Then, create a new account, name it "test" and see how your apps work in that User acct? (That will tell if your problem is systemwide or limited to your User acct.) This account is just for test, do nothing further with it.
Open System Preferences >> Accounts >> "+" make it an admin account.
If the problem is present in the test account also, then it is systemwide. In this case try repairing this with the 10.5.2 Combo Update This is a fuller install, as opposed to an incremental "delta" update so it should overwrite any files that are damaged or missing. It does not matter if you have applied it before.
(Note: If you are running build 9C7010 do not install the Update.)
Remember to Verify Disk before update and repair permissions after update from /Applications/Utilities/Disk Utility.
If the problem does not appear in the test account try starting in "Safe Mode" (It will take a bit more time to startup because it runs a directory check first).
If that works go to System Preferences >> Accounts >> Login Items and remove them. Boot normally and test. If there are still problems, go to ~(yourHome)/Library/Contextual Menu Items and move whatever is there to the desktop. Then do the same with /Library/Contextual Menu Items. Lastly, try moving /Users/Home)/Library/Fonts to your desktop and restarting.
Log out/in or restart, if that sorts it start putting items back one at a time until you find the culprit.
Let us know.
-mj

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    Welcome to Apple Discussions.
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