Finder - Cannot double click items to open

Since I upgraded to Snow Leopard, intermittently I have been unable to double click some items to open them in their default programs. I can go into the program and open them via File - Open.
If I double click an item with it's default program open, nothing happens. If I double click an item and the program is not open, the program bounces in the dock and does not open.
Same for .dmg files. If I download them, I can only open them using Disk Utility.
These problems are not present when I boot up. They only happen at some point later. A restart fixes the problem.
Anyone else experiencing this?

I am having the same issue with my machine, and 3 other iMac machines. All updated to 10.6.1. At first I thought it was just attachments in e-mails not opening correctly... Then I discovered that double-clicking, or right (option) clicking and choosing open, or open with, did not do anything. If the default program for that file is open, it will take you to the program but will not open anything. I have found this to be a problem with .pdf, .doc, .docx, .jpg files. I tried deleting the finder preference file, which has done nothing. No solutions as of yet.

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    ewaller wrote:
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  • Bridge CS6 crashes with double-click, not with "open with"

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    Have made comments on this in Photoshop forum, but have not solved problem yet.  http://forums.adobe.com/thread/1184356?tstart=0

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    Bridge cs6 keeps crashing whenever I double click on a file (jpg/psd/raw files).
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    well it never worked, and I installed several times. I kept working with bridge CS5, but I have a new camera with raw files only supported in CS6, so now I'm confronted with this problem again.
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    Faulting application name: Bridge.exe, version: 5.0.2.4, time stamp: 0x50d99f7a
    Faulting module name: unknown, version: 0.0.0.0, time stamp: 0x00000000
    Exception code: 0xc0000005
    Fault offset: 0x0012f9f8
    Faulting process id: 0x17a0
    Faulting application start time: 0x01ce30d973f12912
    Faulting application path: C:\Program Files\Adobe\Adobe Bridge CS6\Bridge.exe
    Faulting module path: unknown
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