Firefox no longer opens, and neither does Profile Manager

So yesterday some website from a Google search (Kilauea photos search string) did something wacky, and now Firefox 4.0.1 will not start. Safe mode doesn't start. Profile Manager won't start either. Uninstalling Firefox, removing Firefox's folder from Program Files, running a registry cleaner to clean up Firefox leftovers, running a full MS Security Essentials scan which did find some nasty trojans, and then reinstalling Firefox only works for the initial session. A rerun of Security Essentials, and a run with IObit's Malware Fighter find nothing. Once I close and restart, same as in the beginning. Internet Explorer 8 and the 3.7a5pre Minefield version of Firefox seem to run normally other than Minefield fails to remember passwords even though it's checked. Any ideas on what to try?

I tried Firefox 3.7. I tried Firefox 5 beta. Same thing kept happening. Searches for similar situations just wasn't turning up a viable solution. I may have finally figured it out though. What to do when in doubt? Start doing searches on the processes running in Task Manager. All antivirus programs I have installed have FAILED to recognize this executable as malicious. Look for an executable in your Task Manager that says hdmclean.exe. It will be under ~\users\***\appdata\local. It must be a variant (at least in name) of hddclean.exe. As soon as I terminated the process I was able to launch Firefox 5 beta. I went ahead and deleted the damn bastard, and then rebooted. Seems to have solved the problem as far as I can tell.

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    ''cor-el [[#answer-668399|said]]''
    <blockquote>
    It is possible that your security software (firewall, anti-virus) blocks or restricts Firefox or the plugin-container process without informing you, possibly after detecting changes (update) to the Firefox program.
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    *https://support.mozilla.org/kb/fix-problems-connecting-websites-after-updating
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    *Malwarebytes' Anti-Malware:<br>http://www.malwarebytes.org/mbam.php
    *AdwCleaner:<br>http://www.bleepingcomputer.com/download/adwcleaner/<br>http://www.softpedia.com/get/Antivirus/Removal-Tools/AdwCleaner.shtml
    *SuperAntispyware:<br>http://www.superantispyware.com/
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    *Windows Defender:<br>http://windows.microsoft.com/en-us/windows/using-defender
    *Spybot Search & Destroy:<br>http://www.safer-networking.org/en/index.html
    *Kasperky Free Security Scan:<br>http://www.kaspersky.com/security-scan
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    *https://support.mozilla.org/kb/troubleshoot-firefox-issues-caused-malware
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