Firefox problems - Can't open from Downloads - Can't print - FF will not update and more and more...

I've been having several problems with Firefox, to the point that I almost can't use it anymore. In no particular order, they include:
1. When I download something, 'Downloads' opens. When a d/l finishes I used to be able to run an install or open an image from there, but now I get this error message,
Windows cannot access the specified device, path of file. You may not have the appropriate permissions to access the item.
...but I can go to my Downloads directory and run or open it from there.
2. If I go to File > Print or File > Print Preview, I get this
Printing Error:
"Before you can perform printer-related tasks such as page setup or printing a document, you need to install a printer. Do you want to install a printer now?"
and if I click yes, i get this,
"Operation could not be completed."
3. Firefox will not update itself. I go to About, it downloads the new update, and I click the Apply Update button. Firefox closes, and nothing happens. A few minutes later I click to run it, and it opens with a 'Software Update' window that says,
Update Failed
"The partial update could not be applied. Firefox will try again by downloading a complete Update"
...and that does not work.
I download the new version, and when trying to run it from Downloads, I get the error (as in #1 above):
"Windows cannot access the specified device, path of file. You may not have the appropriate permissions to access the item."
When I go to the folder it's in and run it from there, it installs, but the problems persist.
4. I go to Help|Troubleshooting Information, and clicking the Reset Firefox button only closes Firefox. Clicking the Show Folder button doesn't do anything.
5. I used to be able to drag a url to the desktop, a folder or even a email, but now all I get the the O with a / through it.
6. I also used to be able to, when I click Browse on a site to upload a jpg or a gif, I could right click the file and open it in a photo viewing program (Irfanview or Paint), and now I get
"Windows cannot access the specified drive, path or file. You may not have the appropriate permissions to access the item."
I've created a new profile and it makes no difference.
I've disabled all add-ons and it makes no difference (I have to disable them manually).
The problems are there for different user accounts in Windows.
I've uninstalled Firefox, and removed the profile - rebooted and reinstalled it, but the problems persist.
What more do I have to do more to completely uninstall it?
I've kinda saved myself by using Firefox Portable, which I'm running from it's own directory. It runs as it should, but I'd prefer not to have to use it.
If i can't fix it, I'd like to completely uninstall Firefox, and just install it new and have it work properly. I have no (or only occasional minor) problems with Firefox on other computers. This computer is Win XP, fully updated

The post I was responding to said,
"Try to boot the computer in Windows Safe mode with network support (press F8 on the boot screen) as a test to see if that helps. "
Somehow, I think that means Windows...
I've tried Firefox in Safe Mode - it makes no difference.

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