First time opening box

I keep getting this box coming up saying it is the first time you have open this program but it is not. Please can anyone help?

Is it in the Applications folder?
Have you checked  "Don't warn me when opening applications on this disk image", forget exactly where that is.
Other possible fixes...
https://discussions.apple.com/thread/3826648?start=0&tstart=0
http://forums.macrumors.com/showthread.php?t=405405

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