Fonts are activated despite being off in Font Book

Question

I opened a Word doc in MS Word 2008 and, all of a sudden, started asking me in a dialog box:
"Microsoft Word want to use the font... "bla bla" ... that was downloaded from the internet. Allow Microsoft Word to use this font?
And then buttons to either "Show in Finder" "Don't Allow" and "Allow"
Some I allowed and some I didn't allow.
This was a document I had previously opened in Word with no problem. These are fonts that were definitely not in the Word doc.
Now, in Word and other applications like InDesign, I have all my fonts activated despite being off or deactivated in Font Book.
That's nearly 100 or so fonts open that I don't need so this is slowing me down.
I've restarted - no luck.
Any ideas?

Answer 1

First try manually removing the Office font cache files. Close all Office applications. Remove the following files. The tilde (~) indicates your home account.
~/Library/Caches/com.microsoft.browserfont.cache
~/Library/Preferences/Microsoft/Office Font Cache (11)
For Office 2008, the location of the second item is:
~/Library/Preferences/Microsoft/Office 2008/Office Font Cache (12)
If that doesn't do it, read on.
Being unable to open or close fonts from within Font Book's interface is almost always a sign its database is damaged. The only fix is to clear it and start over.
Restart your Mac and immediately hold down the Shift key when you hear the startup chime to boot into Safe Mode. Keep holding the Shift key until OS X asks you to log in (you will get this screen on a Safe Mode boot even if your Mac is set to automatically log in). Let the Mac finish booting to the desktop and then restart normally.
This will clear Font Book's database and the cache files of the user account you logged into in Safe Mode. Any font sets you have created will be gone. Also, all fonts in the three main Fonts folders (System, Library, your user account) will now be active, regardless of their state beforehand.
Next, you need to clear all font cache files from the system.
Close all running applications. From an administrator account, open the Terminal app and enter the following command. You can also copy/paste it from here into the Terminal window:
sudo atsutil databases -remove
This removes all font cache files. Both for the system and all user font cache files. After running the command, close Terminal and immediately restart your Mac.