Fonts install now MacBook won't start

Hi!
Just got a new macbook as a mini design machine and installed my font library on it using font book (some 1200 fonts or so). Now the poor thing won't start up. It goes through the motions, but gets to the last stages of startup - spotlight almost appears on the screen - and refuses to go any further.
Are these two things related, does anyone know? On previous machines, I've always used a font manager such as Suitcase and ignored font book, but didn't on this occasion. Should I have used a font manager this time too? Is that quantity of fonts causing the macbook to have memory paroxysms, or does font book only activate fonts on demand like other managers?
So far I have tried all recommended startup troubleshooters, even down to resetting factory settings and flushing the PRAM. I'm just stopping short of re-installng the OS in case anyone can shed any light on this.
Thanks in advance.
MacBook   Mac OS X (10.4.9)  

Thanks for the suggestion. Isn't it amazing that as you get wrapped up in OS progression, you can forget the old-school solutions! LOL.
Have tried this now and deinstalled all those fonts successfully. Unfortunately it didn't solve the problem so was forced into an erase-and-reinstall anyway. I guess it wasn't the fonts in the first place.
Thanks again though.

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