Gmail IMAP suddenly became super slow and folders started disappearing and reappearing - what can I do?

I've been using Thunderbird as an IMAP client for Gmail for about 2 years without any problems. Three days ago I saw for the first time the following message at startup: "Unable to load address book file abook-9.mab. It may be read-only, or locked by another application. Please try again later." Subsequent restarts produced the same message, except the abook number would change to abook-12, abook-10, abook-7, etc. Eventually I gave up and continued using Thunderbird. Performance was suddenly super slow. When I tried to move a message from the Inbox to a folder, the message didn't move; I tried twice more, nothing. So I went to look at the folder, and I got the dreaded message (I'm sorry I don't recall the exact wording) "Unable to access local folder [folder] - [something other possible reason] or your hard drive may be full". But if I would just leave this folder selected, eventually the contents would appear. I tried downloading all my folders for offline use, but after an hour or so they all disappeared. Fortunately, I didn't panic; a few minutes later, they started appearing again. The folders were still present in my local directory, but their contents were all gone: The size of my Mail directory went from 3.85 GB to 107 MB and never fully recovered.
So I went online and started searching. I deleted all the .msf files. Same behavior. I deleted the SystemConfiguration folder on my MacBook. Same behavior. I restored my Profiles and Mail directories with their backups from the day before the trouble started. Same behavior.
And just as I was about to start screaming, I restored the Profiles and Mail directories with their backups from 2 weeks before the trouble started. So far things appear to be going well.
I looked at bug 495911 and bug 893786, but I had already tried most of the things people suggested, so I decided to open a new question. One thing that caught my eye is the recommendation to replace the potentially corrupted file 'panacea.dat' with an earlier version. Is it possible that the 'panacea.dat' file from the day before the problem started was already corrupted and that's why I had to go back to 2 weeks before?
Fortunately, none of the folders or messages were deleted on my online Gmail account (as far as I can tell), but this has definitely been a very frustrating experience...

Try to start *Windows* in safe mode with networking enabled.
- Win8 http://windows.microsoft.com/en-US/windows-8/windows-startup-settings-including-safe-mode
- Win7 http://windows.microsoft.com/en-US/windows7/Start-your-computer-in-safe-mode
- XP http://www.microsoft.com/resources/documentation/windows/xp/all/proddocs/en-us/boot_failsafe.mspx
Still in Windows safe mode, start Thunderbird in safe mode.
- https://support.mozilla.org/en-US/kb/safe-mode
Does the problem go away?

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