Grey screen ,Apple logo and then Prohibited sign

Hope someone can help , when i turn on my macbook pro only get a grey screen with apple logo and then prohibited sign and thats as far as i can get.Have been reading through topics and have tried most things which relate to fixing my problem ,i e tried to boot of install disk but won't let me tried to reset the pram etc but still can't get any futher , last thing i do was to back my macbook pro on a new lacie external hard drive and have no idea weather it backed up everything , macbook pro is 12 months old and have just dropped batterey off as was faulty so have been running direct off power ,i started to back up with the lacie external hard drive when batterey was not in (meaning was running off main power supply ) Would anyone be able to help or give advice on a solution
Thanks for your time
Regards one stressed out mac lover

Try booting off the Installation DVD 1 and once you're past the language selection open Disk Utility (from the menus) and repair your disk permissions.

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