Hard Drive not recognised inside MacBook Pro, however works in enclosure...

And my question is... WHY?!
Basically, my Macbook Pro took a bit of a knock on the hard drive side. Coincidentally, as it was on at the time, (Whoops!), it stopped responding and the colour wheel of death was apparent. I restarted with option held pressed down, so that I can see if the Hard Disk is still being read/recognised. After doing this a couple of times, I noticed that the Hard Disk was becoming intermittent in its ability to being read. I have also used Disk Utility and Disk Warrior and have been getting the same symptoms. I diagnosed, (more of an assumption than anything), that the Hard Disk is broken and I need another one. No biggy! I have a Time Machine drive, which had just that moment finished backing-up! =) Nice!
Anyway, I got a new hard drive (Toshiba 250 GB MK2552GSX Model no.), put it in my Macbook Pro and it, again, is intermittent, therefore fully disproving my theory that it was the Hard Disk itself. (Seeing as it can be read easily in the enclosure.)
Possibly the connector/the logic board it connects to?? I don't know, there's something broken inside my laptop, but just in case somebody out there has a solution, I'd be VERY grateful as it's my laptop I use for my university studies.
Thanks!

Does your old drive work in your external enclosure?
The reason I ask is because I've had this problem, but it happened after I replaced the Hard Drive in my Early 08 MBP (MacBook Pro 4,1). Turns out, the i/o cable, where it attaches to the logic board, gets worn/brittle from heat and very easy to damage. The repair at the genius bar ran about $20 for the cable, but I had a generous genius who waived the standard labor fee after I gave him my sad story, so your milage may vary.
I should also note that the Hard Drive on that generation of MacBook Pro is not considered user upgradable, and your swap will negate your Apple Care, if you have it, until all the damaged components are replaced.
Best of luck.

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