Hard drive prevents waking from sleep

I have a mac mini 2011 2.5Ghz core i5 that has developed an unusual problem. I just got a new Lacie D2 quadra external hard drive and if I leave it connected as the backup I cannot get the computer to wake up. When I move the mouse or tap the keyboard, the screen does not turn on, but the hard drive responds and starts lighting up. This has been happening fairly regularly and the only way I can get the computer to start is to unplug the drive (and suffer the improper disk removal warning upon waking up) or hard restart the computer. I don't know if it matters, but in terms of the rest of the system, I have the mini attached to a 30" cinema display via the thunderbolt and dual-link dvi-to-mini displayport adapter. But again, this just started happening upon connecting the new drive and seems to be remedied by disconnecting or turning off the drive before sleep. Any thoughts, other than always make sure its disconnected? Thanks!

Try Ejecting the External HD before sleeping the Mac.
Then see if the Mac Mini will wake and re-mount the External HD.

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