Hard Drives and Macbook Pro

Say I want to install a program that is over 50 Gigs and I don't have enough room on my internal hard drive to do that.
Is it possible to install that program onto the external hard drive and open the program from there?
I'm thinking of installing Logic Pro.
Sounds stupid but I want to make sure this is possible.
Thanks.

The application is not 50 GB. The _application + supporting_ files combined are ~50 GB. From the Logic Pro specs page:
+*Available disk space*+
+7GB to install all applications and required content+
+Additional 39GB to install all optional content (large content packages can be installed on separate disk):+
+10GB for Jam Pack collections+
+16GB for sound effects+
+6GB for surround music beds+
+7GB for other optional content+
You need to install the 7 GB "all applications and required content" on the internal drive, in the Applications folder - you will run into trouble down the road (e.g. with updates) if you don't. The 39 GB of optional content can go on your external drive, as the specs state.

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