Hard drives, externals, enclosures,... help?

If anyone could lend me their experience and or advice regarding what works well with the MBP (Santa Rosa chip) I would greatly appreciate it. I've attempted to do as much research on this myself, as I understand what works best is subjective a great deal of the time to what you intend to use the space for, however, after much research and acronym discussions +like you wouldn't believe+, I'm fairly confident my brain at this point, is toast.
My primary focus with this drive will be regarding rather large RAW files, working with Aperture and Lightroom, and with any luck being able to do so while hopefully avoiding lagging the workflow process much, if at all. That being, I'm guessing firewire 800, possibly Sata via the expresscard solutions available is the route to take? As far as enclosures and self-built externals go, seagate barracuda's 7200.11 seem to be spot on from what I can find mixed with a lot of people talking up OWC's Mercury Elite.... In the opinion of those familiar with this setup and possibly having made and or used others, would you recommend this option more so than the next or if not, any set reason? Would firewire be fully sufficient for what I'm looking to do or is it worth the money to invest in sata considering progression of technology in that avenue or is this perpendicular recording all it's hyped up to be?
From what I can tell, it seems as though the OWC/Seagate option is the best investment (based on what I'm looking for) in relation to size, speed and overall reliability, but being that I personally have limited knowledge on this subject, I figured I would ask here for any additional insight you guys might be willing to offer.
Thanks for your time.

Hi, mcholley, and welcome to Apple Discussions.
I can't suggest any remedy for your optical drive not reading audio CDs but having no trouble with data CDs, except to say it's apparently a software problem, not hardware-based.
After replacing your hard drive, did you reinstall your operating system from scratch on it, or did you restore your OS from a backup you had made?
The disappearance of your external drives (are they USB or FireWire?) may be power-related. Are they externally powered, or are you powering them from the USB or FireWire bus? If they're bus-powered, are you connecting both of them at once? That won't work: together they demand more power from the bus than it can supply, and while they may spin, they won't mount. Connect only one of them at a time. Is either of them detected by Apple System Profiler when just one is connected to the Powerbook? Does it mount on the desktop then?
If you've been able to connect both drives to the Powerbook at the same time in the past, and both have mounted OK, then there's been some hardware change recently, other than your hard drive replacement, that has caused the loss of external drive detection. Is it possible that during your recent operations you've turned off one or both of the external drives, or disconnected it/them from the Powerbook, without dismounting it from the desktop first? Depending on what, if anything, the drive was doing at the time, that can make a FireWire drive unmountable and all the data on it inaccessible. In that case it may be necessary to erase and reformat the drive. I don't know whether the same is true of USB drives.
Do you have another Mac to which you can connect the drives, to see whether they show up on it? If they do, you might have to consider the possibility that the port(s) to which you've been connecting them on your Powerbook is bad.

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