Have malware and mac running slow, how do I solve this problem

EtreCheck version: 1.9.12 (48)
Report generated June 21, 2014 at 7:14:19 AM EDT
Hardware Information:
  iMac (21.5-inch, Late 2012) (Verified)
  iMac - model: iMac13,1
  1 2.7 GHz Intel Core i5 CPU: 4 cores
  8 GB RAM
Video Information:
  NVIDIA GeForce GT 640M - VRAM: 512 MB
  iMac 1600 x 900
System Software:
  OS X 10.9.3 (13D65) - Uptime: 2 days 10:11:57
Disk Information:
  APPLE HDD ST1000LM024 disk0 : (1 TB)
  EFI (disk0s1) <not mounted>: 209.7 MB
  disk0s2 (disk0s2) <not mounted>: 999.35 GB
  Recovery HD (disk0s3) <not mounted>: 650 MB
USB Information:
  STECH    Simple Drive     400.09 GB
  disk2s1 (disk2s1) <not mounted>: 32 KB
  External HD (disk2s3) /Volumes/External HD: 399.95 GB (74.72 GB free)
  Apple Inc. FaceTime HD Camera (Built-in)
  Apple Inc. MacBook Air SuperDrive
  Apple Inc. BRCM20702 Hub
  Apple Inc. Bluetooth USB Host Controller
Thunderbolt Information:
  Apple Inc. thunderbolt_bus
Gatekeeper:
  Mac App Store and identified developers
Kernel Extensions:
  [loaded] com.symantec.kext.SymAPComm (12.6f28 - SDK 10.6) Support
  [loaded] com.symantec.kext.filesecurity (2.6f32) Support
  [loaded] com.symantec.kext.fw (5.3f12) Support
  [loaded] com.symantec.kext.internetSecurity (5.3f6) Support
  [loaded] com.symantec.kext.ips (3.9.1f10) Support
  [loaded] com.symantec.kext.pf (5.6f22) Support
Launch Daemons:
  [loaded] com.adobe.fpsaud.plist Support
  [loaded] com.adobe.SwitchBoard.plist Support
  [loaded] com.oracle.java.Helper-Tool.plist Support
  [loaded] com.oracle.java.JavaUpdateHelper.plist Support
  [running] com.symantec.deepsight-extractor.plist Support
  [failed] com.symantec.errorreporter-periodic.plist Support
  [loaded] com.symantec.liveupdate.daemon.ondemand.plist Support
  [loaded] com.symantec.liveupdate.daemon.plist Support
  [not loaded] com.symantec.nav.migrateqtf.plist Support
  [running] com.symantec.sharedsettings.plist Support
  [running] com.symantec.symdaemon.plist Support
  [not loaded] com.vsearch.daemon.plist Support
  [running] com.vsearch.helper.plist Support
  [running] com.zeobit.MacKeeper.plugin.AntiTheft.daemon.plist Support
Launch Agents:
  [not loaded] com.adobe.AAM.Updater-1.0.plist Support
  [loaded] com.adobe.CS5ServiceManager.plist Support
  [loaded] com.oracle.java.Java-Updater.plist Support
  [loaded] com.symantec.errorreporter-periodicagent.plist Support
  [loaded] com.symantec.nis.application.plist Support
  [running] com.symantec.uiagent.application.plist Support
  [running] com.vsearch.agent.plist Support
User Launch Agents:
  [loaded] com.adobe.AAM.Updater-1.0.plist Support
  [loaded] com.adobe.ARM.[...].plist Support
  [loaded] com.citrixonline.GoToMeeting.G2MUpdate.plist Support
  [failed] com.zeobit.MacKeeper.Helper.plist Support
  [not loaded] jp.co.canon.Inkjet_Extended_Survey_Agent.plist Support
User Login Items:
  iTunesHelper
  Canon IJ Network Scanner Selector EX
  AdobeResourceSynchronizer
  TuneupMyMac
Internet Plug-ins:
  Flip4Mac WMV Plugin: Version: 3.2.0.16   - SDK 10.8 Support
  FlashPlayer-10.6: Version: 14.0.0.125 - SDK 10.6 Support
  Default Browser: Version: 537 - SDK 10.9
  AdobePDFViewerNPAPI: Version: 11.0.07 - SDK 10.6 Support
  AdobePDFViewer: Version: 11.0.07 - SDK 10.6 Support
  Flash Player: Version: 14.0.0.125 - SDK 10.6 Support
  QuickTime Plugin: Version: 7.7.3
  NortonInternetSecurityBF: Version: 1.9.0 - SDK 10.6 Support
  Silverlight: Version: 5.1.20913.0 - SDK 10.6 Support
  JavaAppletPlugin: Version: Java 7 Update 60 Check version
Safari Extensions:
  Norton Internet Security: Version: 1.9.0f7
Audio Plug-ins:
  BluetoothAudioPlugIn: Version: 1.0 - SDK 10.9
  AirPlay: Version: 2.0 - SDK 10.9
  AppleAVBAudio: Version: 203.2 - SDK 10.9
  iSightAudio: Version: 7.7.3 - SDK 10.9
iTunes Plug-ins:
  Quartz Composer Visualizer: Version: 1.4 - SDK 10.9
User Internet Plug-ins:
  CitrixOnlineWebDeploymentPlugin: Version: 1.0.105 Support
  ConduitNPAPIPlugin: Version: 1.0 - SDK 10.6 Support
3rd Party Preference Panes:
  Flash Player  Support
  Flip4Mac WMV  Support
  Growl  Support
  Java  Support
  Norton\nQuickMenu  Support
Time Machine:
  Mobile backups: OFF
  Auto backup: NO - Auto backup turned off
  Volumes being backed up:
  Destinations:
  External HD [Local] (Last used)
  Total size: 372.49 GB
  Total number of backups: (null)
  Size of backup disk: Excellent
  Backup size 372.49 GB > (Disk size 0 B X 3)
  Time Machine details may not be accurate.
  All volumes being backed up may not be listed.
Top Processes by CPU:
      1% WindowServer
      1% fontd
      0% com.apple.WebKit.Networking
      0% Safari
      0% configd
Top Processes by Memory:
  434 MB SymDaemon
  279 MB WindowServer
  270 MB com.apple.WebKit.WebContent
  180 MB Mail
  156 MB Safari
Virtual Memory Information:
  2.21 GB Free RAM
  3.41 GB Active RAM
  1.40 GB Inactive RAM
  991 MB Wired RAM
  1.47 GB Page-ins
  0 B Page-outs

In addition to Symantec and MacKeeper as QuickTimeKirk suggested, remove adware Vsearch too.
Identify and remove adware
http://www.thesafemac.com/arg/
or
Adware Removal Tool
http://www.thesafemac.com/art/

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