Having difficulties with my Magic Cordless Mouse

I got home from a long trip last night and updated my software on my new i7 iMac.  Then, I needed to change the batteries on my cordless mouse.  Ever since, the mouse is recognized (I can move the cursor around the screen), but when I left click, nothing happens.  I CAN right click, however, and can control SOME things that way.  Any ideas what is going on?
Please help!
Marsue

You may have a corrupt cache. Restart in Safe Mode, this will clear some caches. If that still doesn't work then do both a iMac SMC and PRAM resets. And finally if those do not help then re-pair the mouse using:
http://support.apple.com/kb/HT2845

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