Having the problem to open the application

my macbook is having the problem i cant open the mail,imessage,contact,appstore, it try already by pressing Cmd alt +P R but still the same.

Go step by step and test.
1. Turn off proxies, if selected.
    System Preference > Network > Advanced  > Proxies Tab
    Under "Select Protocol", uncheck any box if selected.
    Click "OK" then  "Apply".
2. Power Cycle
   Power off the router. Unplug it from the wall. Wait a while.
   Plug it back to the wall. Power the router on. Wait until all the lights are lit properly.
   It will take a while.
   Restart the computer.
   Start up in Safe Mode.
   http://support.apple.com/kb/PH11212?viewlocale=en_US
3. Turn off Extensions, if any.
    Safari > Preferences > Extensions

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